T-02
Azelaic acid strength-evidence explorer
The per-compound data component: every study in the monograph, filterable by the concentration it tested (10%, 15%, 20%, mixed), with design, n, outcome and claim ids. Makes the concentration-evidence gap a browsable fact rather than a slogan.
The per-compound data component: every study in the monograph, filterable by the concentration it tested (10%, 15%, 20%, mixed), with design, n, outcome and claim ids. Makes the concentration-evidence gap a browsable fact rather than a slogan.
Published records (4 of 4)
| Concentration tier | Regulatory status | Evidence at this strength |
|---|---|---|
| 10% (cosmetic serums) | Cosmetic; no FDA premarket review; not an OTC drug monograph ingredient | 1 randomized study: 8-week, 23-person split-face test of a 0.1% retinal + 10% azelaic acid COMBINATION measuring texture, redness and pores. No monotherapy RCT for acne, rosacea or melasma at this strength. |
| 15% (Rx gel and foam) | FDA-approved prescription drugs (NDA 021470, NDA 207071, generic ANDAs); indication: rosacea papules and pustules | Pivotal programs in 664 (gel) and 1362 (foam) subjects; superiority over metronidazole 0.75%; acne equivalence trials vs benzoyl peroxide 5% and clindamycin 1%; adult female acne vs adapalene; PIH open-label pilot. |
| 20% (Rx cream) | FDA-approved prescription drug (NDA 020428); indication: mild-to-moderate inflammatory acne | Acne trials vs vehicle, tretinoin 0.05% and oral tetracycline; rosacea split-face vs metronidazole; melasma double-blind trials vs hydroquinone 4% (equal) and 2% (superior); alopecia areata pilot; ranked first for rosacea IGA improvement in the 2025 network meta-analysis. |
| Mixed / synthesis rows | Reviews and meta-analyses spanning strengths | Cochrane 2015 (high-quality evidence, rosacea), GRADE 2019 (high certainty), 2025 rosacea NMA, 2021 melasma NMA, 2019 melasma SR, 2023 umbrella SR. |
Every row restates a published record; sources resolve on the sourced monograph. Species is part of the data: this table never scales an animal dose into a human figure.
Tools: educational calculators and references only.